Cold Spring Harbor Laboratory Archives • FRAXA Research Foundation

Roles of Postnatal Transient Connectivity in the Development of Fragile X Syndrome

August 9, 2023

This team is studying why people with Fragile X are overly sensitive to sound and light, using advanced imaging to find brain changes and test ways to prevent them.

Karel Svoboda, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Intracortical Circuitry in the Barrel Cortex of FMR1-KO Mice

February 22, 2005

With $40,000 in funding from FRAXA Research Foundation in 2005, Dr. Karel Svoboda and his team at the Cold Spring Harbor Laboratory imaged neocortical circuits in Fragile X mice to determine the functions of the abnormal dendritic spines found in Fragile X syndrome.

Holly Cline, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

FMRP Function in the Xenopus Visual System

February 27, 2004

With a $75,000 grant from FRAXA Research Foundation from 2003-2004, Dr. Holly Cline and her team at Cold Spring Harbor Labratory studied Fragile X proteins and related mRNA regulations in tadpoles.

Robert Malinow, PhD, at Cold Spring Harbor Laboratory, FRAXA research grant

Studies of glutamate receptor trafficking

August 1, 2001

FRAXA awarded $35,000 in 2001 to Robert Malinow, PhD, Principal Investigator and Julius Zhu, PhD, FRAXA Postdoctoral Fellow at Cold Spring Harbor Laboratory. While he was a postdoctoral fellow in Dr. Malinow’s lab, Dr. Julius Zhu carried out experiments designed to define the set of proteins which are affected in Fragile X syndrome and understand how they function together. In 2002, Dr. Zhu started his own lab at the University of Virginia where he is continuing his Fragile X work with new funding from FRAXA.