One of the features of the Fragile X mouse model which is relevant to the human Fragile X syndrome (and autism) is social behavior. Several tests show consistent social behavioral abnormalities in the Fragile X mouse model. With a $140,000 grant from FRAXA Research Foundation in 2012-2013, Dr. Willemsen at Erasmus University used social behavior tests to measure the effectiveness of several drug strategies.
Read moreErasmus University Rotterdam
Role of the Cerebellum in the Dysfunction of Fragile X Syndrome
Correcting Fragile X Syndrome Deficits by Targeting Neonatal PKCε Signaling in the Brain Ben A. Oostra, PhD Principal Investigator Erasmus University Rotterdam, The Netherlands 2004-2005 Grant Funding: $119,000 Summary The Dutch-Belgian Fragile X Consortium led by Dr. Oostra created the
Read moreMouse Models of Fragile X Syndrome
Dr. Ben Oostra and his team at Erasmus University completed and published multiple studies related to Fragile X syndrome. They created the first Fragile X knockout mouse model and went on to perform many critical studies in Fragile X mouse models.
Read moreReactivating the FMR1 Gene
With a $171,600 grant from FRAXA Research Foundation from 1998-2004, Dr. Andre Hoogeveen and his team at Erasmus University researched methods to reactivate the Fragile X gene.
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