Drosophila CYFIP, a Molecular Link Between Actin Cytoskeleton Remodeling and Fragile X

Drosophila CYFIP, a Molecular Link Between Actin Cytoskeleton Remodeling and Fragile X

Angela Giangrande, PhD, Universite Louis Pasteur, FRAXA research grant

Angela Giangrande, PhD
Principal Investigator

Universite Louis Pasteur
Strasbourg, France

2004-2006 Grant Funding: $130,000

Summary

Dr. Angela Giangrande at the Universite Louis Pasteur investigated the interactions between dendrites, messenger mRNA, and the cytoskeleton in fruit flies, which are a simple yet powerful system in which multiple genes can be manipulated with relative ease.

The Science

by Angela Giangrande, 1/1/2004

The normal function of FMRP, the protein missing in Fragile X, involves two primary actions:

1. regulation of protein synthesis in dendrites, and

2. transport of messenger RNA from the nucleus of the cell to the dendrites.

Both these functions require significant interactions with the cytoskeleton, the scaffold which holds the cell together. In the first instance, cytoskeletal changes (dendritic spines become long and thin) occur whenever LTD (Long Term Depression) occurs, and this is known to occur too much in Fragile X. In the second case, transport of mRNA requires that FMRP hook onto the cytoskeleton and propel itself along, like a railroad train, to transport the mRNA to the dendrite, where it will be used as the template for protein synthesis. Clearly, these two functions are closely related, and both appear to be stimulated by activation of metabotropic glutamate receptors.

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Global Leader in Fragile X Research

FRAXA-funded researchers around the world are leading the way towards effective treatments and ultimately a cure.

Explore Current Research Grants
Help Fund the Cure