Role of Experience in Regulating Levels of the Fragile X Protein

FRAXA Research Foundation 1994-2000 Grants • Disease Mechanisms • Mack, Kenneth • Mayo Clinic • Todd, Peter January 1, 2004March 17, 2025glutamate, NIH, PSD-95, seizure

Role of Experience in Regulating Levels of the Fragile X Protein

Kenneth J. Mack, MD, PhD, at Mayo Clinic, FRAXA research grant

Kenneth J. Mack, MD, PhD
Principal Investigator

Peter K. Todd, MD, PhD
Postdoctoral Fellow

Mayo Clinic
Rochester, MN

FRAXA Awards:
$29,000 in 2001
$20,000 in 2000

The Science

Final Report on Dr. Mack’s Project

While a professor at University of Wisconsin-Madison, Dr. Mack investigated whether and how FMRP levels are regulated in response to neuronal stimulation in vivo (in live animals). He looked at the effects of seizures and of experience in his experiments.

Dr. Mack and colleagues published their findings in the Proceedings of the National Academy of Sciences:

The Fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

Peter K. Todd, Kenneth J. Mack, and James S. Malter

PNAS | November 25, 2003 | vol. 100 | no. 24