Prefrontal Cortex Network (PFC) Dynamics in Fragile X Syndrome

Prefrontal Cortex Network (PFC) Dynamics in Fragile X Syndrome

Dan Johnston and Jennifer Seigel

Daniel Johnston, PhD
Principal Investigator

Jennifer Siegel, PhD
FRAXA Fellow

University of Texas at Austin

2016-2017 Grant Funding: $90,000

Summary

Dr. Daniel Johnston and Dr. Jennifer Siegel at the University of Texas at Austin are analyzing pre-frontal cortex (PFC) dysfunction in the Fragile X model. They have preliminary evidence that Fragile X mice are severely impaired in a prefrontal cortex (PFC)-dependent task.

The Science

“We are taking a slightly different approach to treating and potentially curing Fragile X,” said Dr. Johnston, professor, Department of Neuroscience, College of Natural Sciences, and Director, Center for Learning & Memory, The University of Texas at Austin. “We are studying how a small proportion of Fragile X mice are able to overcome the dysfunction and learn. In this way, function can potentially be restored. If it is not realistic to fix the many neuronal differences observed in the absence of FMRP, perhaps letting nature tell us how a non-FMRP brain can be functional may be a promising approach for intervention.”

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Global Leader in Fragile X Research

FRAXA-funded researchers around the world are leading the way towards effective treatments and ultimately a cure.

Explore Current Research Grants
Help Fund the Cure