Structure of FMRP

Structure of FMRP

Lynne Regan

Lynne Regan, PhD
Principal Investigator

Yale University
New Haven, CT

2001-2002 Grant Funding: $68,000

Summary

With a $68,000 grant from FRAXA Research Foundation from 2001-2002, Dr. Lynne Regan at Yale University studied different protein shapes and how they contributed towards different functions for Fragile X syndrome. Results published.

The Results

Results Published: Valverde R, Pozdnyakova I, Kajander T,Venkatraman J, Regan L. 2007 Fragile X, Structure of the KH1-KH2 Domains of Fragile X ProteinStructure, 15:1090-1098.

The Science

Dr. Lynne Regan is an expert in the 3-dimensional structure of proteins.  This kind of research is fundamental to understanding how proteins function and how mutations in particular parts of a protein can altar its function.

In the case of FMRP, the Fragile X protein, there are several functional domains.  It appears that each functional domain does something different, which may explain why FMRP appears to have several different functions in the brain.  It is critical to understand these various functions if we hope to compensate for the loss of FMRP.  Dr. Regan has studied several of the sections of FMRP which bind to other proteins and mRNAs.

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FRAXA-funded researchers around the world are leading the way towards effective treatments and ultimately a cure.

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Global Leader in Fragile X Research

FRAXA-funded researchers around the world are leading the way towards effective treatments and ultimately a cure.

Explore Current Research Grants
Help Fund the Cure