neural network Archives

FMRP Regulatory Role in Human Hippocampal Development and Therapeutic Interventions in Fragile X

October 16, 2025

Fragile X syndrome hippocampal organoids show neuron–glia imbalance. This team will map disrupted gene networks and test PDE inhibitors to restore brain function.

Modeling Fragile X Syndrome using Multi-Region Human Brain Organoids

May 16, 2023

Discover groundbreaking research at UCI by Dr. Watanabe and Dr. Tsai. Using cutting-edge organoid technology, they’re modeling Fragile X brain function and advancing potential treatment testing.

Auditory Dysfunction in Fragile X Syndrome in a Mouse Model of Fragile X

April 5, 2021

With a $90,000 grant from FRAXA, Dr. McCullagh and Dr. Achem Klug at the University of Colorado investigated whether auditory neural circuits are altered in Fragile X mice. They saw minor differences in these mice compared to B6 (control) mice in several measures of auditory acuity. Fmr1 mice had increased latency to the startle response for almost all conditions compared to B6 mice, suggesting altered timing to acoustic cues. These experiments show that, consistent with patient reports and anatomical/physiological data, the auditory system is altered in a mouse model of FXS, though with some potential compensation leading to a subtle behavioral impact.

Nazim Kourdougli and Carlos Portera-Cailleau

Correcting Sensory Processing in Fragile X Mice by Modulating Kv3.1

June 19, 2019

FRAXA awarded a $90,000 grant to Carlos Portera-Cailliau, PhD and Nazim Kourdougli, PhD at UCLA to investigate whether a novel drug can rescue sensory processing deficits in Fragile X mice. People with Fragile X have similar problems in sensory processing. This new drug acts on Kv3.1, a promising Fragile X treatment target also being pursued by UK-based Autifony Therapeutics based on FRAXA-funded research done at Yale.

Computational Analysis of Neural Circuit Disruption in Fragile X Model Mice

September 12, 2014

Computer modeling of the brain offers the hope of predicting how the brain responds to varying conditions, but these models have been rather primitive until recently. The Sejnowski team at the Salk Institute, who specialize in computational models of neural networks, will take the results of previous FRAXA-funded projects and incorporate them into their advanced computer models of brain function.

Mina Johnson-Glenberg, PhD, at University of Wisconsin, FRAXA research grant

Neural Network Model of Working Memory in Fragile X Syndrome

February 27, 2000

With a $67,000 grant from FRAXA Research Foundation in 2000, Dr. Mina Johnson-Glenberg at the University of Wisconsin researched how long-term and working memory was affected in individuals with Fragile X syndrome.

FMRP Regulatory Role in Human Hippocampal Development and Therapeutic Interventions in Fragile X

Modeling Fragile X Syndrome using Multi-Region Human Brain Organoids

Auditory Dysfunction in Fragile X Syndrome in a Mouse Model of Fragile X

Correcting Sensory Processing in Fragile X Mice by Modulating Kv3.1

Computational Analysis of Neural Circuit Disruption in Fragile X Model Mice

Neural Network Model of Working Memory in Fragile X Syndrome

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