sleep Archives • Page 2 of 2 • FRAXA Research Foundation

Sleep and Circadian Rhythms in Fragile X Mutant Drosophila

FRAXA Research Foundation February 14, 2008August 5, 2021

Ravi Allada, MD, at Northwestern University, FRAXA research grant

With an $80,000 grant from FRAXA Research Foundation over 2 years, Dr. Ravi Allada and his team studied at Northwestern University sleep behaviors in Fragile X fruit flies. These fruit flies are useful for several important reasons; not only do they have a good cognitive phenotype, they also have a clear disturbance of circadian rhythms. This is an important model for human hyperactivity and sleep disorders, and this group studied the underlying mechanisms in an effort to find treatments for the human conditions.

Melatonin Clinical Trial in Fragile X

FRAXA Research Foundation February 27, 2000March 9, 2020

With a $60,000 grant from FRAXA Research Foundation from 1998-1999, Dr. Randi Hagerman and her team at the University of California studied the effects of different compounds on individuals with Fragile X syndrome, focusing specifically on melatonin. Results published.